Opium is perhaps the oldest example of a drug that has been used for medicine and recreation, and has been used in this way since antiquity, with its first recorded use believed to be in Mesopotamia over 5,000 years ago. Though laudanum, a solution opium in ethyl alcohol, was popular in the 19th century, opium itself was banned from many countries in the 20th century. However, its derivatives including codeine, morphine and heroin are still manufactured today.
In 1804 Friedrich Stertürner isolated morphine from the opium poppy. He found that the product he had discovered induced euphoria and was a far stronger analgesic than opium. He named it morphine after Morpheus, the Greek god of dreams.
In 1874 and 1897, it was discovered that morphine could be refined to produce heroin. This new drug was originally marketed as a cough suppressant (particularly for children!) and as a cure for morphine addiction. Once in the body, heroin metabolises into morphine- an extremely embarrassing discovery for the company concerned! It was more widely used after the introduction of the hypodermic needle. Bela Lugosi, who played Dracula in the 1931 film, is said to have become addicted to morphine in the 1940s after suffering a back injury, though he later managed to overcome his addiction.
This analgesic is also found in the opium poppy. Though it is synthesized from morphine, it is less potent and addictive. It may originally have been prepared in c.1715 by the chemist Lemart in the Netherlands, though it was first isolated in in 1832 in France by Pierre Robiquest.
Howard Hughes’ post mortem showed lethal levels of codeine following his death aged 70 in 1976. After his death, x-rays showed five needles in his arms which had broken off when he injected codeine.
Obtained from the leaves of the coca plant, cocaine was first isolated in 1855 by Friedrich Gaedick and named erythroxyline. It was purified in 1860 by Albert Niemann and renamed cocaine. It first use as an anaesthetic was by Dr Carl Koller who applied a cocaine solution to his eye and then pricked it with pins. Its use as a spinal anaesthetic was discovered by Heinrich Quincke in 1898, who described a technique of lumbar puncture which was later used by August Bier in his experiments on spinal anaesthetic. Addiction to cocaine amongst doctors during the late 19th and early 20th centuries was surprisingly common, with one estimate at 30% of doctors and dentists.
Cocaine can still be used as a local anaesthetic, though rarely and often in combination with other synthesised drugs.
Nitrous Oxide or ‘Laughing Gas’
Though nitrous oxide was first synthesized by Joseph Priestly in 1772, it was then prepared and thoroughly tested by 19 year-old Humphry Davy in 1798. Davy recognised the analgesic properties of the gas and its potential to be used in surgeries, though it was almost fifty years until it was taken up.
Laughing gas parties or ‘ether frolics’ became popular amongst the upper classes from 1799, when nitrous oxide or diethyl ether was inhaled to induce feelings of euphoria.
Since Wells’ first public demonstration in 1844, nitrous oxide has been used as a light anaesthetic and analgesic and is still used as a self-administered analgesic in obstetrics and also in surgery, where it is used as a light anaesthetic before stronger drugs are added.
This rapid onset, shorter-acting anaesthetic is administered by intravenous injection. Ernest H Volwiter and Donalee L Tabern at Abbott Laboratories in the early 1930s. It continued to be manufactured at Abbott until 2004.
Though a more modern drug than those above, it has just a dark and controversial a history as drugs such as opium and morphine.
One alternative use for it is as a truth serum. Doctors using it as an anaesthetic noticed that patients became disinhibited and talkative just before they lost consciousness. As a barbiturate, it slows down the messages that are sent to the brain and slows down the thought process, making it difficult to think clearly and thus to maintain a convincing lie. However, this process also makes the patient more suggestible and not necessarily truthful.
It has also been used as an execution tool. In 34 US states it was used as part of the lethal injection. Ohio was the first state to use a large single dose rather than a three drug cocktail, which also includes Pancuronium and potassium chloride. In 2010, the sole American supplier of sodium thiopental announced that production would stop.
Watch the clip below to discover what happened to BBC presenter Michael Moseley when he tried to convince doctors he was a famous heart surgeon, after a dose of sodium thiopental.
This anaesthetic was developed by Parke-Davis in 1962 and given to American soldiers in the Vietnam War, where it was known as the ‘buddy drug’ because it could be administered by another soldier. It was primarily used in veterinary medicine. More recently is has become known as a drug that may be used for date rape.
Perhaps not as well-known as ketamine and sodium thiopental, but far more widespread in the mid-20th century, Oblivon or methylpentynol was a hypnotic sedative with anticonvulsant effects. Developed in the 1950s, it was marketed as ‘the confidence pill’ and supposed to help with visits to the dentist, public speaking, job interviews and other potentially nerve-wracking events. Up to 1 million pills were sold weekly until 1955, when it became limited to prescriptions.
The reasons for behind this restriction was the reports of a burglary earlier in 1955. Two young men, aged 18 and 20, took Oblivon capsules to give them the courage to break into a house. The 18 year old drove away on a stolen motorbike and crashed, killing the 20 year old who was riding pillion.
First synthesized by Paul Janssen in 1960, fentanyl is used for both anaesthesia and analgesia.
It is believed that a derivative of this drug was used by the Russian authorities to end the Moscow theatre siege in 2002, the use of which killed 40 attackers and around 140 hostages.
Isolated by the Japanese chemist Nagayoshi Nagai in 1885, ephedrine is a stimulant used by athletes when training as it can be used to relax the airways. It is banned in most drug tested sports.
Ephedrine is said to have been found in the bodies of Michael Jackson and River Phoenix in their post mortems.
Tuinal, Secobarbital (Seconal) and Amobarbital (Amytal)
This piece is a combined holder for three drugs: tuinal, secobarbital and amobarbital. All of these are barbiturates and are said to have been responsible for the deaths of well-known figures.
Tuinal is a mixture of barbiturate salts secobarbital sodium and amobarbital sodium and which was developed back in the late 1940s by Eli Lilly. It acts as a sedative and has many references in popular culture. It has been claimed that Sid Vicious of the Sex Pistols took Tuinal on the night that his girlfriend, Nancy Spungen, died of stab wound. He died the following year in 1979.
Amobarbital, an analgesic barbiturate, was first synthesized in Germany in 1923. It has been suggested that this drug contributed to the death of actor Robert Walker in 1951, and that he suffered a severe reaction to this drug in combination with alcohol.
Secobarbital is another anaesthetic and sedative that was developed in the 1920s in Germnay. It was widely misused in the 1960s and 1970s, with reports of overdoses from this drug. The alleged cause of Judy Garland’s death was an accidental overdose of barbiturates. Her blood is said to have contained the equivalent of 10 seconal capsules.